(Somewhat bias, I am an upstream maintainer)

Currently, after the release of the steam natives, midi support breaks unless you manually preload them in launch args and install fluidsynth on your system. You may also need to download a soundfont in order to not have terrible instruments and place it into ~/.local/share/Space Station 14/data/soundfonts/

The game also uses an old version of glfw on linux which may cause some issues for users with non qwerty keyboard layouts (and also will use x11 if you are not into that). Which you can also preload and my launch args include. Make sure to rename the old glfw in steamapps/common/Space Station 14/bin/loader/ with something like .old in the end so it won't load since I otherwise found it caused issues at launch (and maybe also the fluidsynth dll I don't remember if it did anything but as of writing I commented it out apparently).

You may have to customize these for your distro, just find where all the libraries exist on your system with locate after installing them.

The game is still perfectly playable otherwise without any extra args. But it is recommended.